{"id":6755,"date":"2025-08-27T20:03:30","date_gmt":"2025-08-27T17:03:30","guid":{"rendered":"https:\/\/www.rheumatology.bg\/?p=6755"},"modified":"2025-08-28T20:01:10","modified_gmt":"2025-08-28T17:01:10","slug":"bimzelx-bimekizumab","status":"publish","type":"post","link":"https:\/\/www.rheumatology.bg\/?p=6755","title":{"rendered":"Bimzelx (bimekizumab) &#8211; \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f, \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0430, \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438"},"content":{"rendered":"<div class=\"wpb-content-wrapper\" id=\"wpb-content-root\"><p data-start=\"456\" data-end=\"809\"><strong data-start=\"456\" data-end=\"471\">\u0411\u0438\u043c\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431<\/strong> (\u0442\u044a\u0440\u0433\u043e\u0432\u0441\u043a\u043e \u043d\u0430\u0438\u043c\u0435\u043d\u043e\u0432\u0430\u043d\u0438\u0435 <strong data-start=\"496\" data-end=\"507\">Bimzelx<\/strong>) \u0435 <strong data-start=\"511\" data-end=\"549\">\u0447\u043e\u0432\u0435\u0448\u043a\u043e \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u043d\u043e \u0430\u043d\u0442\u0438\u0442\u044f\u043b\u043e IgG1<\/strong>, \u043a\u043e\u0435\u0442\u043e <strong data-start=\"557\" data-end=\"625\">\u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u0431\u043b\u043e\u043a\u0438\u0440\u0430 \u043a\u0430\u043a\u0442\u043e \u0438\u043d\u0442\u0435\u0440\u043b\u0435\u0432\u043a\u0438\u043d\u201117A (IL\u201117A), \u0442\u0430\u043a\u0430 \u0438 IL\u201117F<\/strong> \u2013 \u0434\u0432\u0430 \u043a\u043b\u044e\u0447\u043e\u0432\u0438 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u0430, \u0443\u0447\u0430\u0441\u0442\u0432\u0430\u0449\u0438 \u0432 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435 \u043f\u0440\u0438 \u043f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442 (PsA), \u0430\u043d\u043a\u0438\u043b\u043e\u0437\u0438\u0440\u0430\u0449 \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u0438\u0442 (AS), \u043d\u0435\u0440\u0430\u0434\u0438\u043e\u0433\u0440\u0430\u0444\u0441\u043a\u0438 \u0430\u043a\u0441\u0438\u0430\u043b\u0435\u043d \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u043e\u0430\u0440\u0442\u0440\u0438\u0442 (nr-axSpA) \u0438 \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441.<\/p>\n<p data-start=\"811\" data-end=\"1030\">\u0417\u0430 \u0440\u0430\u0437\u043b\u0438\u043a\u0430 \u043e\u0442 \u0434\u0440\u0443\u0433\u0438 IL\u201117 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438 (\u043d\u0430\u043f\u0440. \u0441\u0435\u043a\u0443\u043a\u0438\u043d\u0443\u043c\u0430\u0431, \u0438\u043a\u0441\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431), \u043a\u043e\u0438\u0442\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0442 <strong data-start=\"897\" data-end=\"918\">\u0441\u0430\u043c\u043e \u0432\u044a\u0440\u0445\u0443 IL\u201117A<\/strong>, \u0431\u0438\u043c\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431 \u043f\u043e\u0442\u0438\u0441\u043a\u0430 <strong data-start=\"940\" data-end=\"952\">\u0438 IL\u201117F<\/strong>, \u043a\u043e\u0439\u0442\u043e \u0438\u043c\u0430 <strong data-start=\"964\" data-end=\"996\">\u043f\u043e\u0434\u043e\u0431\u043d\u0430 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442<\/strong> \u0438 \u0447\u0435\u0441\u0442\u043e \u0435 \u043a\u043e\u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u0440\u0430\u043d \u0441 IL\u201117A.<\/p>\n<h3 data-start=\"1429\" data-end=\"1460\"><strong data-start=\"1435\" data-end=\"1460\">\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u043d\u0430 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/strong><\/h3>\n<ul data-start=\"1462\" data-end=\"1764\">\n<li data-start=\"1462\" data-end=\"1600\">\n<p data-start=\"1464\" data-end=\"1600\">IL\u201117A \u0438 IL\u201117F \u0441\u0430 \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u043f\u0440\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u0438, \u043f\u0440\u043e\u0438\u0437\u0432\u0435\u0436\u0434\u0430\u043d\u0438 \u043e\u0442 <strong data-start=\"1534\" data-end=\"1549\">Th17 \u043a\u043b\u0435\u0442\u043a\u0438<\/strong>, <strong data-start=\"1551\" data-end=\"1566\">\u03b3\u03b4\u2011T \u043a\u043b\u0435\u0442\u043a\u0438<\/strong>, <strong data-start=\"1568\" data-end=\"1583\">ILC3 \u043a\u043b\u0435\u0442\u043a\u0438<\/strong> \u0438 <strong data-start=\"1586\" data-end=\"1600\">\u043d\u0435\u0443\u0442\u0440\u043e\u0444\u0438\u043b\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"1601\" data-end=\"1764\">\n<p data-start=\"1603\" data-end=\"1620\">\u0418 \u0434\u0432\u0430\u0442\u0430 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u0430:<\/p>\n<ul data-start=\"1623\" data-end=\"1764\">\n<li data-start=\"1623\" data-end=\"1670\">\n<p data-start=\"1625\" data-end=\"1670\">\u0421\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0430\u0442 \u043f\u0440\u043e\u0434\u0443\u043a\u0446\u0438\u044f \u043d\u0430 \u0445\u0435\u043c\u043e\u043a\u0438\u043d\u0438 \u0438 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u0438<\/p>\n<\/li>\n<li data-start=\"1673\" data-end=\"1710\">\n<p data-start=\"1675\" data-end=\"1710\">\u041f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0442 \u043d\u0435\u0443\u0442\u0440\u043e\u0444\u0438\u043b\u043d\u0430 \u0438\u043d\u0444\u0438\u043b\u0442\u0440\u0430\u0446\u0438\u044f<\/p>\n<\/li>\n<li data-start=\"1713\" data-end=\"1764\">\n<p data-start=\"1715\" data-end=\"1764\">\u0410\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u0442 \u0444\u0438\u0431\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u0438, \u043e\u0441\u0442\u0435\u043e\u043a\u043b\u0430\u0441\u0442\u0438 \u0438 \u043a\u0435\u0440\u0430\u0442\u0438\u043d\u043e\u0446\u0438\u0442\u0438<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-start=\"1766\" data-end=\"1899\"><strong data-start=\"1766\" data-end=\"1781\">\u0411\u0438\u043c\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431<\/strong> \u0431\u043b\u043e\u043a\u0438\u0440\u0430 <strong data-start=\"1790\" data-end=\"1822\">\u0435\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e IL\u201117A \u0438 IL\u201117F<\/strong>, \u043e\u0441\u0438\u0433\u0443\u0440\u044f\u0432\u0430\u0439\u043a\u0438 \u043f\u043e-\u0448\u0438\u0440\u043e\u043a\u0430 \u0438 \u043f\u043e-\u0434\u044a\u043b\u0431\u043e\u043a\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0446\u0438\u044f \u043d\u0430 Th17-\u043e\u0441\u043d\u043e\u0432\u043d\u043e\u0442\u043e \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435.<\/p>\n<h3 data-start=\"1037\" data-end=\"1086\"><strong data-start=\"1042\" data-end=\"1086\">\u041e\u0434\u043e\u0431\u0440\u0435\u043d\u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u0432 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430 (\u0415\u0421)<\/strong><\/h3>\n<ul data-start=\"1088\" data-end=\"1422\">\n<li data-start=\"1088\" data-end=\"1180\">\n<p data-start=\"1090\" data-end=\"1180\"><strong data-start=\"1090\" data-end=\"1118\">\u041f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442 (PsA)<\/strong> \u2013 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u0444\u043e\u0440\u043c\u0430, \u043a\u0430\u0442\u043e \u043c\u043e\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438\u043b\u0438 \u0432 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u0441 DMARDs<\/p>\n<\/li>\n<li data-start=\"1181\" data-end=\"1338\">\n<p data-start=\"1183\" data-end=\"1224\"><strong data-start=\"1183\" data-end=\"1210\">\u0410\u043a\u0441\u0438\u0430\u043b\u0435\u043d \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u043e\u0430\u0440\u0442\u0440\u0438\u0442<\/strong>, \u0432\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u043d\u043e:<\/p>\n<ul data-start=\"1227\" data-end=\"1338\">\n<li data-start=\"1227\" data-end=\"1275\">\n<p data-start=\"1229\" data-end=\"1275\"><strong data-start=\"1229\" data-end=\"1275\">\u0410\u043d\u043a\u0438\u043b\u043e\u0437\u0438\u0440\u0430\u0449 \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u0438\u0442 (radiographic axSpA)<\/strong><\/p>\n<\/li>\n<li data-start=\"1278\" data-end=\"1338\">\n<p data-start=\"1280\" data-end=\"1338\"><strong data-start=\"1280\" data-end=\"1338\">\u041d\u0435\u0440\u0430\u0434\u0438\u043e\u0433\u0440\u0430\u0444\u0441\u043a\u0438 axSpA (nr\u2011axSpA) \u0441 \u043e\u0431\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 data-start=\"1906\" data-end=\"1937\"><strong data-start=\"1912\" data-end=\"1937\">\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0438 \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435<\/strong><\/h3>\n<p data-start=\"1939\" data-end=\"2040\">\u0411\u0438\u043c\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431 \u0441\u0435 \u043f\u0440\u0438\u043b\u0430\u0433\u0430 <strong data-start=\"1962\" data-end=\"1974\">\u043f\u043e\u0434\u043a\u043e\u0436\u043d\u043e<\/strong> \u0447\u0440\u0435\u0437 \u043f\u0440\u0435\u0434\u0432\u0430\u0440\u0438\u0442\u0435\u043b\u043d\u043e \u043d\u0430\u043f\u044a\u043b\u043d\u0435\u043d\u0430 <strong data-start=\"2004\" data-end=\"2018\">\u0441\u043f\u0440\u0438\u043d\u0446\u043e\u0432\u043a\u0430<\/strong> \u0438\u043b\u0438 <strong data-start=\"2023\" data-end=\"2039\">\u0430\u0432\u0442\u043e\u0438\u043d\u0436\u0435\u043a\u0442\u043e\u0440<\/strong>.<\/p>\n<p data-start=\"2042\" data-end=\"2077\"><strong data-start=\"2048\" data-end=\"2077\">\u041f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442 (PsA):<\/strong><\/p>\n<ul data-start=\"2079\" data-end=\"2191\">\n<li data-start=\"2079\" data-end=\"2125\">\n<p data-start=\"2081\" data-end=\"2125\"><strong data-start=\"2081\" data-end=\"2091\">160 mg<\/strong> \u043f\u043e\u0434\u043a\u043e\u0436\u043d\u043e <strong data-start=\"2101\" data-end=\"2123\">\u043d\u0430 \u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"2079\" data-end=\"2125\">\u041f\u0440\u0438 \u041f\u0441\u0410 + \u0443\u043c\u0435\u0440\u0435\u043d \u0434\u043e \u0442\u0435\u0436\u044a\u043a \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441<\/li>\n<li data-start=\"2126\" data-end=\"2191\">\n<ul>\n<li data-start=\"2460\" data-end=\"2552\">\n<p data-start=\"2462\" data-end=\"2552\"><strong data-start=\"2462\" data-end=\"2475\">\u0418\u043d\u0434\u0443\u043a\u0446\u0438\u044f:<\/strong><br data-start=\"2475\" data-end=\"2478\" \/>320 mg (<strong data-start=\"2488\" data-end=\"2514\">\u0434\u0432\u0435 \u0438\u043d\u0436\u0435\u043a\u0446\u0438\u0438 \u043f\u043e 160 mg<\/strong>) \u043d\u0430 <strong data-start=\"2519\" data-end=\"2552\">\u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438 \u0434\u043e \u0441\u0435\u0434\u043c\u0438\u0446\u0430 16<\/strong><\/p>\n<\/li>\n<li data-start=\"2553\" data-end=\"2609\">\n<p data-start=\"2555\" data-end=\"2609\"><strong data-start=\"2555\" data-end=\"2575\">\u041f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0449\u0430 \u0434\u043e\u0437\u0430:<\/strong><br data-start=\"2575\" data-end=\"2578\" \/>320 mg \u043d\u0430 <strong data-start=\"2590\" data-end=\"2609\">\u0432\u0441\u0435\u043a\u0438 8 \u0441\u0435\u0434\u043c\u0438\u0446\u0438, (<\/strong>\u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u043d\u0430\u0434 120 \u043a\u0433 &#8211; \u043c\u043e\u0436\u0435 \u0438 \u043d\u0430<strong data-start=\"2590\" data-end=\"2609\"> \u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438)<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-start=\"2193\" data-end=\"2213\">\u041c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430:<\/p>\n<ul data-start=\"2214\" data-end=\"2289\">\n<li data-start=\"2214\" data-end=\"2233\">\n<p data-start=\"2216\" data-end=\"2233\"><strong data-start=\"2216\" data-end=\"2233\">\u0421\u0430\u043c\u043e\u0441\u0442\u043e\u044f\u0442\u0435\u043b\u043d\u043e<\/strong><\/p>\n<\/li>\n<li data-start=\"2234\" data-end=\"2289\">\n<p data-start=\"2236\" data-end=\"2289\">\u0418\u043b\u0438 <strong data-start=\"2240\" data-end=\"2270\">\u0432 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u0441 \u043c\u0435\u0442\u043e\u0442\u0440\u0435\u043a\u0441\u0430\u0442<\/strong> \u0438\u043b\u0438 \u0434\u0440\u0443\u0433\u0438 csDMARDs<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2296\" data-end=\"2346\"><strong data-start=\"2302\" data-end=\"2346\">\u0410\u043a\u0441\u0438\u0430\u043b\u0435\u043d \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u043e\u0430\u0440\u0442\u0440\u0438\u0442 (AS \u0438 nr\u2011axSpA):<\/strong><\/p>\n<ul data-start=\"2348\" data-end=\"2422\">\n<li data-start=\"2348\" data-end=\"2390\">\n<p data-start=\"2350\" data-end=\"2390\"><strong data-start=\"2350\" data-end=\"2388\">160 mg \u043f\u043e\u0434\u043a\u043e\u0436\u043d\u043e \u043d\u0430 \u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"2391\" data-end=\"2422\">\n<p data-start=\"2393\" data-end=\"2422\">\u0411\u0435\u0437 \u043d\u0443\u0436\u0434\u0430 \u043e\u0442 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u043d\u0430 \u0444\u0430\u0437\u0430<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"3105\" data-end=\"3136\"><strong data-start=\"3111\" data-end=\"3136\">\u041f\u0440\u0435\u0434\u0438\u043c\u0441\u0442\u0432\u0430 \u043d\u0430 Bimzelx<\/strong><\/h3>\n<ul data-start=\"3138\" data-end=\"3438\">\n<li data-start=\"3138\" data-end=\"3217\">\n<p data-start=\"3140\" data-end=\"3217\"><strong data-start=\"3140\" data-end=\"3172\">\u0414\u0432\u043e\u0439\u043d\u0430 IL\u201117A\/IL\u201117F \u0431\u043b\u043e\u043a\u0430\u0434\u0430<\/strong> \u2013 \u043f\u043e-\u0446\u0435\u043b\u0435\u043d\u0430\u0441\u043e\u0447\u0435\u043d\u043e \u0438 \u043f\u043e-\u0434\u044a\u043b\u0431\u043e\u043a\u043e \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/p>\n<\/li>\n<li data-start=\"3218\" data-end=\"3266\">\n<p data-start=\"3220\" data-end=\"3266\"><strong data-start=\"3220\" data-end=\"3264\">\u0411\u044a\u0440\u0437 \u0435\u0444\u0435\u043a\u0442 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0436\u043d\u0438 \u0438 \u0441\u0442\u0430\u0432\u043d\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"3267\" data-end=\"3360\">\n<p data-start=\"3269\" data-end=\"3360\"><strong data-start=\"3269\" data-end=\"3299\">\u0414\u044a\u043b\u044a\u0433 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b \u043d\u0430 \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435<\/strong> (\u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u0440\u0438 \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441 \u2013 \u043d\u0430 \u0432\u0441\u0435\u043a\u0438 8 \u0441\u0435\u0434\u043c\u0438\u0446\u0438 \u0441\u043b\u0435\u0434 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044f)<\/p>\n<\/li>\n<li data-start=\"3361\" data-end=\"3405\">\n<p data-start=\"3363\" data-end=\"3405\"><strong data-start=\"3363\" data-end=\"3383\">\u0414\u043e\u0431\u0440\u0430 \u043f\u043e\u043d\u043e\u0441\u0438\u043c\u043e\u0441\u0442<\/strong>, \u043d\u0438\u0441\u043a\u0430 \u0438\u043c\u0443\u043d\u043e\u0433\u0435\u043d\u043d\u043e\u0441\u0442<\/p>\n<\/li>\n<li data-start=\"3406\" data-end=\"3438\">\n<p data-start=\"3408\" data-end=\"3438\"><strong data-start=\"3408\" data-end=\"3438\">\u041e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u043a\u0430\u0442\u043e \u043c\u043e\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"3445\" data-end=\"3481\"><strong data-start=\"3451\" data-end=\"3481\">\u041d\u0435\u0436\u0435\u043b\u0430\u043d\u0438 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u0438 \u0440\u0438\u0441\u043a\u043e\u0432\u0435<\/strong><\/h3>\n<p data-start=\"3483\" data-end=\"3493\"><strong data-start=\"3483\" data-end=\"3493\">\u0427\u0435\u0441\u0442\u0438:<\/strong><\/p>\n<ul data-start=\"3494\" data-end=\"3611\">\n<li data-start=\"3494\" data-end=\"3534\">\n<p data-start=\"3496\" data-end=\"3534\">\u0418\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u043d\u0430 \u0433\u043e\u0440\u043d\u0438\u0442\u0435 \u0434\u0438\u0445\u0430\u0442\u0435\u043b\u043d\u0438 \u043f\u044a\u0442\u0438\u0449\u0430<\/p>\n<\/li>\n<li data-start=\"3535\" data-end=\"3558\">\n<p data-start=\"3537\" data-end=\"3558\">\u0418\u043d\u0436\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u0438 \u0440\u0435\u0430\u043a\u0446\u0438\u0438<\/p>\n<\/li>\n<li data-start=\"3559\" data-end=\"3611\">\n<p data-start=\"3561\" data-end=\"3611\">\u0414\u0438\u0430\u0440\u0438\u044f, \u0433\u0430\u0434\u0435\u043d\u0435, \u0433\u044a\u0431\u0438\u0447\u043d\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 (\u043d\u0430\u043f\u0440. \u043a\u0430\u043d\u0434\u0438\u0434\u043e\u0437\u0430)<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3613\" data-end=\"3639\"><strong data-start=\"3613\" data-end=\"3639\">\u041f\u043e-\u0441\u0435\u0440\u0438\u043e\u0437\u043d\u0438, \u043d\u043e \u0440\u0435\u0434\u043a\u0438:<\/strong><\/p>\n<ul data-start=\"3640\" data-end=\"3932\">\n<li data-start=\"3640\" data-end=\"3713\">\n<p data-start=\"3642\" data-end=\"3713\"><strong data-start=\"3642\" data-end=\"3674\">\u041a\u0430\u043d\u0434\u0438\u0434\u043e\u0437\u0430 (\u0432\u043a\u043b. \u0435\u0437\u043e\u0444\u0430\u0433\u0435\u0430\u043b\u043d\u0430)<\/strong> \u2013 \u043f\u043e-\u0447\u0435\u0441\u0442\u043e \u043e\u0442 \u043f\u0440\u0438 Cosentyx \u0438\u043b\u0438 Taltz<\/p>\n<\/li>\n<li data-start=\"3714\" data-end=\"3820\">\n<p data-start=\"3716\" data-end=\"3820\"><strong data-start=\"3716\" data-end=\"3757\">IBD (\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u043e \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435): <\/strong>\u0412\u044a\u0437\u043c\u043e\u0436\u043d\u043e <strong data-start=\"3773\" data-end=\"3786\">\u0432\u043b\u043e\u0448\u0430\u0432\u0430\u043d\u0435<\/strong> \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441 \u043f\u0440\u0435\u0434\u0448\u0435\u0441\u0442\u0432\u0430\u0449\u043e IBD<\/p>\n<\/li>\n<li data-start=\"3821\" data-end=\"3846\">\n<p data-start=\"3823\" data-end=\"3846\"><strong data-start=\"3823\" data-end=\"3844\">\u0425\u0438\u043f\u0435\u0440\u0441\u0435\u043d\u0437\u0438\u0442\u0438\u0432\u043d\u043e\u0441\u0442<\/strong><\/p>\n<\/li>\n<li data-start=\"3847\" data-end=\"3932\">\n<p data-start=\"3849\" data-end=\"3932\"><strong data-start=\"3849\" data-end=\"3873\">\u041f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438<\/strong> \u2013 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438 \u0441\u0430 \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433 \u0437\u0430 \u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u043e\u0437\u0430 \u0438 \u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0445\u0435\u043f\u0430\u0442\u0438\u0442\u0438<\/p>\n<\/li>\n<\/ul>\n<p><strong data-start=\"5280\" data-end=\"5305\">Bimzelx (\u0431\u0438\u043c\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431)<\/strong> \u0435 \u043d\u0430\u0439-\u043d\u043e\u0432\u0438\u044f\u0442 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u0438\u0442\u0435\u043b \u043d\u0430 IL\u201117 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438\u0442\u0435, \u043a\u043e\u0439\u0442\u043e \u043f\u0440\u0435\u0434\u043b\u0430\u0433\u0430 <strong data-start=\"5370\" data-end=\"5409\">\u043f\u043e-\u0448\u0438\u0440\u043e\u043a\u043e \u043f\u043e\u0442\u0438\u0441\u043a\u0430\u043d\u0435 \u043d\u0430 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u0442\u043e<\/strong> \u0447\u0440\u0435\u0437 \u0435\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430 \u0431\u043b\u043e\u043a\u0430\u0434\u0430 \u043d\u0430 <strong data-start=\"5439\" data-end=\"5458\">IL\u201117A \u0438 IL\u201117F<\/strong>. \u0421 \u043e\u0442\u043b\u0438\u0447\u043d\u0430 \u0435\u0444\u0438\u043a\u0430\u0441\u043d\u043e\u0441\u0442 \u043f\u0440\u0438 <strong data-start=\"5485\" data-end=\"5498\">\u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441<\/strong>, <strong data-start=\"5500\" data-end=\"5522\">\u043f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442<\/strong> \u0438 <strong data-start=\"5525\" data-end=\"5552\">\u0430\u043a\u0441\u0438\u0430\u043b\u0435\u043d \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u043e\u0430\u0440\u0442\u0440\u0438\u0442<\/strong>, \u0442\u043e\u0439 \u0441\u0435 \u0443\u0442\u0432\u044a\u0440\u0436\u0434\u0430\u0432\u0430 \u043a\u0430\u0442\u043e \u043e\u0431\u0435\u0449\u0430\u0432\u0430\u0449\u0430 \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0430 \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u0435\u043d \u0435\u0444\u0435\u043a\u0442 \u0438\u043b\u0438 \u043d\u0435\u043f\u043e\u043d\u043e\u0441\u0438\u043c\u043e\u0441\u0442 \u043a\u044a\u043c TNF-\u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438 \u0438\u043b\u0438 \u043a\u043b\u0430\u0441\u0438\u0447\u0435\u0441\u043a\u0438 IL\u201117 \u0431\u043b\u043e\u043a\u0435\u0440\u0438.<\/p>\n<p>[vc_row][vc_column][vc_cta h2=&#8220;&#8220; h4=&#8220;\u0422\u044a\u0440\u0441\u0438\u0442\u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433, \u043a\u043e\u0439\u0442\u043e \u0438\u043c\u0430 \u043e\u043f\u0438\u0442 \u0441 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f?&#8220; style=&#8220;custom&#8220; add_button=&#8220;bottom&#8220; btn_title=&#8220;\u0417\u0430\u043f\u0430\u0437\u0438 \u0447\u0430\u0441 \u0437\u0430 \u043f\u0440\u0435\u0433\u043b\u0435\u0434&#8220; btn_style=&#8220;custom&#8220; btn_custom_background=&#8220;#E64946&#8243; btn_custom_text=&#8220;#FFFFFF&#8220; btn_align=&#8220;center&#8220; btn_i_icon_fontawesome=&#8220;fa fa-solid fa-calendar&#8220; css=&#8220;&#8220; btn_add_icon=&#8220;true&#8220; custom_background=&#8220;#FFDED6&#8243; btn_link=&#8220;url:https%3A%2F%2Fwww.rheumatology.bg%2F%3Fpage_id%3D5548|title:%D0%97%D0%B0%D0%BF%D0%B0%D0%B7%D0%B8%20%D1%87%D0%B0%D1%81%20%D0%B7%D0%B0%20%D0%BF%D1%80%D0%B5%D0%B3%D0%BB%D0%B5%D0%B4%20%D1%81%D0%B5%D0%B3%D0%B0&#8243;]\u0414-\u0440 \u041a\u043e\u043f\u0447\u0435\u0432 \u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433 \u0432 \u0421\u043e\u0444\u0438\u044f, \u043a\u043e\u0439\u0442\u043e \u043f\u0440\u043e\u0441\u043b\u0435\u0434\u044f\u0432\u0430 \u0433\u043e\u043b\u044f\u043c \u0431\u0440\u043e\u0439 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438, \u043f\u0440\u043e\u0432\u0435\u0436\u0434\u0430\u0449\u0438 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0417\u0430\u043f\u0430\u0437\u0435\u0442\u0435 \u0447\u0430\u0441 \u0437\u0430 \u043f\u0440\u0435\u0433\u043b\u0435\u0434 \u0441\u0435\u0433\u0430.[\/vc_cta][vc_cta h2=&#8220;&#8220; h4=&#8220;\u0412\u044a\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442 \u0437\u0430 \u043e\u043d\u043b\u0430\u0439\u043d \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f&#8220; style=&#8220;custom&#8220; add_button=&#8220;bottom&#8220; btn_title=&#8220;\u041e\u043d\u043b\u0430\u0439\u043d \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f&#8220; btn_style=&#8220;custom&#8220; btn_custom_background=&#8220;#7360F2&#8243; btn_custom_text=&#8220;#FFFFFF&#8220; btn_align=&#8220;center&#8220; btn_i_icon_fontawesome=&#8220;fa fa-brands fa-viber&#8220; css=&#8220;&#8220; btn_add_icon=&#8220;true&#8220; custom_background=&#8220;#D8D4F2&#8243; btn_link=&#8220;url:https%3A%2F%2Fwww.rheumatology.bg%2F%3Fpage_id%3D171|title:%D0%9E%D1%82%D0%B4%D0%B0%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B0%20%D0%BA%D0%BE%D0%BD%D1%81%D1%83%D0%BB%D1%82%D0%B0%D1%86%D0%B8%D1%8F&#8220;]\u0410\u043a\u043e \u0436\u0435\u043b\u0430\u0435\u0442\u0435 \u0431\u044a\u0440\u0437 \u043e\u0442\u0433\u043e\u0432\u043e\u0440 \u043d\u0430 \u0432\u0430\u0448\u0438\u0442\u0435 \u0432\u044a\u043f\u0440\u043e\u0441\u0438, \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u0442\u0435 \u043e\u043d\u043b\u0430\u0439\u043d \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f \u043f\u043e Viber, WhatsApp \u0438\u043b\u0438 \u0438\u043c\u0435\u0439\u043b. \u0417\u0430 \u043f\u043e\u0432\u0435\u0447\u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f \u043e\u0442\u043d\u043e\u0441\u043d\u043e \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438\u0442\u0435 \u0441\u0442\u044a\u043f\u043a\u0438 \u0438 \u0446\u0435\u043d\u0438, \u043d\u0430\u0442\u0438\u0441\u043d\u0435\u0442\u0435 \u0431\u0443\u0442\u043e\u043d\u0430 \u043f\u043e-\u0434\u043e\u043b\u0443.[\/vc_cta][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>\u0411\u0438\u043c\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431 (\u0442\u044a\u0440\u0433\u043e\u0432\u0441\u043a\u043e \u043d\u0430\u0438\u043c\u0435\u043d\u043e\u0432\u0430\u043d\u0438\u0435 Bimzelx) \u0435 \u0447\u043e\u0432\u0435\u0448\u043a\u043e \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u043d\u043e \u0430\u043d\u0442\u0438\u0442\u044f\u043b\u043e IgG1, \u043a\u043e\u0435\u0442\u043e \u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u0431\u043b\u043e\u043a\u0438\u0440\u0430 \u043a\u0430\u043a\u0442\u043e \u0438\u043d\u0442\u0435\u0440\u043b\u0435\u0432\u043a\u0438\u043d\u201117A (IL\u201117A), \u0442\u0430\u043a\u0430 \u0438 IL\u201117F \u2013 \u0434\u0432\u0430 <a class=\"mh-excerpt-more\" href=\"https:\/\/www.rheumatology.bg\/?p=6755\" title=\"Bimzelx (bimekizumab) &#8211; \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f, \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0430, \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":6756,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50,11],"tags":[],"class_list":["post-6755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biologichni","category-medikamenti"],"_links":{"self":[{"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/posts\/6755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6755"}],"version-history":[{"count":4,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/posts\/6755\/revisions"}],"predecessor-version":[{"id":6801,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/posts\/6755\/revisions\/6801"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=\/wp\/v2\/media\/6756"}],"wp:attachment":[{"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rheumatology.bg\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}