{"id":6751,"date":"2025-08-27T14:12:20","date_gmt":"2025-08-27T11:12:20","guid":{"rendered":"https:\/\/www.rheumatology.bg\/?p=6751"},"modified":"2025-08-28T20:00:53","modified_gmt":"2025-08-28T17:00:53","slug":"taltz-ixekizumab","status":"publish","type":"post","link":"https:\/\/www.rheumatology.bg\/?p=6751","title":{"rendered":"Taltz (ixekizumab) &#8211; \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f, \u0434\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0430, \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438"},"content":{"rendered":"<div class=\"wpb-content-wrapper\" id=\"wpb-content-root\"><p><strong data-start=\"363\" data-end=\"378\">\u0418\u043a\u0441\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431<\/strong> (\u0442\u044a\u0440\u0433\u043e\u0432\u0441\u043a\u043e \u043d\u0430\u0438\u043c\u0435\u043d\u043e\u0432\u0430\u043d\u0438\u0435 <strong data-start=\"403\" data-end=\"412\">Taltz<\/strong>) \u0435 <strong data-start=\"416\" data-end=\"475\">\u043d\u0430\u043f\u044a\u043b\u043d\u043e \u0445\u0443\u043c\u0430\u043d\u0438\u0437\u0438\u0440\u0430\u043d\u043e \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u043d\u043e \u0430\u043d\u0442\u0438\u0442\u044f\u043b\u043e \u043e\u0442 \u043a\u043b\u0430\u0441 IgG4<\/strong>, \u043a\u043e\u0435\u0442\u043e \u0441\u0435 \u0441\u0432\u044a\u0440\u0437\u0432\u0430 \u0441 <strong data-start=\"496\" data-end=\"524\">\u0438\u043d\u0442\u0435\u0440\u043b\u0435\u0432\u043a\u0438\u043d 17A (IL\u201117A)<\/strong> \u2013 \u043a\u043b\u044e\u0447\u043e\u0432 \u0446\u0438\u0442\u043e\u043a\u0438\u043d \u0432 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0430\u0442\u0430 \u043d\u0430 <strong data-start=\"560\" data-end=\"574\">\u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441\u0430<\/strong>, <strong data-start=\"576\" data-end=\"605\">\u043f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u043d\u0438\u044f \u0430\u0440\u0442\u0440\u0438\u0442 (PsA)<\/strong> \u0438 <strong data-start=\"608\" data-end=\"640\">\u0430\u043d\u043a\u0438\u043b\u043e\u0437\u0438\u0440\u0430\u0449\u0438\u044f \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u0438\u0442 (AS)<\/strong>.<\/p>\n<h3 data-start=\"1111\" data-end=\"1140\"><strong data-start=\"1115\" data-end=\"1140\">\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u043d\u0430 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435<\/strong><\/h3>\n<p data-start=\"1142\" data-end=\"1234\">IL-17A \u0438\u0433\u0440\u0430\u0435 \u043a\u043b\u044e\u0447\u043e\u0432\u0430 \u0440\u043e\u043b\u044f \u0432\u044a\u0432 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u043a\u043e\u0436\u0430\u0442\u0430, \u0435\u043d\u0442\u0435\u0437\u0438\u0442\u0435 \u0438 \u0441\u0442\u0430\u0432\u0438\u0442\u0435 \u0447\u0440\u0435\u0437 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435 \u043d\u0430:<\/p>\n<ul data-start=\"1236\" data-end=\"1354\">\n<li data-start=\"1236\" data-end=\"1254\">\n<p data-start=\"1238\" data-end=\"1254\"><strong data-start=\"1238\" data-end=\"1252\">\u041d\u0435\u0443\u0442\u0440\u043e\u0444\u0438\u043b\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"1255\" data-end=\"1274\">\n<p data-start=\"1257\" data-end=\"1274\"><strong data-start=\"1257\" data-end=\"1272\">Th17 \u043a\u043b\u0435\u0442\u043a\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"1275\" data-end=\"1354\">\n<p data-start=\"1277\" data-end=\"1354\"><strong data-start=\"1277\" data-end=\"1307\">\u0424\u0438\u0431\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u0438 \u0438 \u043a\u0435\u0440\u0430\u0442\u0438\u043d\u043e\u0446\u0438\u0442\u0438<\/strong>, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0442 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u043d \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u0435\u043d \u043e\u0442\u0433\u043e\u0432\u043e\u0440<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1356\" data-end=\"1510\">\u0418\u043a\u0441\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431 \u0441\u0435 \u0441\u0432\u044a\u0440\u0437\u0432\u0430 \u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u0438 \u0441 \u0432\u0438\u0441\u043e\u043a\u0430 \u0441\u0438\u043b\u0430 \u043a\u044a\u043c IL\u201117A, \u043a\u0430\u0442\u043e <strong data-start=\"1423\" data-end=\"1478\">\u043f\u0440\u0435\u0434\u043e\u0442\u0432\u0440\u0430\u0442\u044f\u0432\u0430 \u043d\u0435\u0433\u043e\u0432\u043e\u0442\u043e \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438\u0442\u0435<\/strong> \u0438 \u0441\u043f\u0438\u0440\u0430 \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0430\u0442\u0430 \u043a\u0430\u0441\u043a\u0430\u0434\u0430.<\/p>\n<h3 data-start=\"821\" data-end=\"855\"><strong data-start=\"825\" data-end=\"855\">\u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u0432 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430<\/strong><\/h3>\n<p data-start=\"857\" data-end=\"887\">Taltz \u0435 \u043e\u0434\u043e\u0431\u0440\u0435\u043d \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430:<\/p>\n<ul data-start=\"889\" data-end=\"1104\">\n<li data-start=\"889\" data-end=\"966\">\n<p data-start=\"891\" data-end=\"966\"><strong data-start=\"891\" data-end=\"919\">\u041f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442 (PsA)<\/strong> \u2013 \u043a\u0430\u0442\u043e \u043c\u043e\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438\u043b\u0438 \u0432 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u0441 DMARDs<\/p>\n<\/li>\n<li data-start=\"967\" data-end=\"1001\">\n<p data-start=\"969\" data-end=\"1001\"><strong data-start=\"969\" data-end=\"999\">\u0410\u043d\u043a\u0438\u043b\u043e\u0437\u0438\u0440\u0430\u0449 \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u0438\u0442 (AS)<\/strong><\/p>\n<\/li>\n<li data-start=\"1002\" data-end=\"1063\">\n<p data-start=\"1004\" data-end=\"1063\"><strong data-start=\"1004\" data-end=\"1061\">\u041d\u0435\u0440\u0430\u0434\u0438\u043e\u0433\u0440\u0430\u0444\u0441\u043a\u0430 \u0430\u043a\u0441\u0438\u0430\u043b\u043d\u0430 \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u043e\u0430\u0440\u0442\u0440\u043e\u043f\u0430\u0442\u0438\u044f (nr-axSpA)<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"1517\" data-end=\"1546\"><strong data-start=\"1521\" data-end=\"1546\">\u0414\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0438 \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435<\/strong><\/h3>\n<p data-start=\"1548\" data-end=\"1685\">\u0418\u043a\u0441\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431 \u0441\u0435 \u043f\u0440\u0438\u043b\u0430\u0433\u0430 <strong data-start=\"1571\" data-end=\"1583\">\u043f\u043e\u0434\u043a\u043e\u0436\u043d\u043e<\/strong>, \u0447\u0440\u0435\u0437 \u0430\u0432\u0442\u043e\u0438\u043d\u0436\u0435\u043a\u0442\u043e\u0440 \u0438\u043b\u0438 \u043f\u0440\u0435\u0434\u0432\u0430\u0440\u0438\u0442\u0435\u043b\u043d\u043e \u043d\u0430\u043f\u044a\u043b\u043d\u0435\u043d\u0430 \u0441\u043f\u0440\u0438\u043d\u0446\u043e\u0432\u043a\u0430. \u0421\u0445\u0435\u043c\u0430\u0442\u0430 \u043d\u0430 \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0437\u0430\u0432\u0438\u0441\u0438 \u043e\u0442 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0435\u0442\u043e:<\/p>\n<h4 data-start=\"1687\" data-end=\"1722\">\u2705 <strong data-start=\"1694\" data-end=\"1722\">\u041f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442 (PsA)<\/strong><\/h4>\n<ul data-start=\"1724\" data-end=\"1979\">\n<li data-start=\"1724\" data-end=\"1805\">\n<p data-start=\"1726\" data-end=\"1805\"><strong data-start=\"1726\" data-end=\"1743\">\u041d\u0430\u0447\u0430\u043b\u043d\u0430 \u0434\u043e\u0437\u0430:<\/strong><br data-start=\"1743\" data-end=\"1746\" \/><strong data-start=\"1748\" data-end=\"1758\">160 mg<\/strong> (2 \u0438\u043d\u0436\u0435\u043a\u0446\u0438\u0438 \u043f\u043e 80 mg) <strong data-start=\"1781\" data-end=\"1791\">\u0432\u0435\u0434\u043d\u044a\u0436<\/strong>, \u0432 \u043f\u044a\u0440\u0432\u0438\u044f \u0434\u0435\u043d<\/p>\n<\/li>\n<li data-start=\"1807\" data-end=\"1866\">\n<p data-start=\"1809\" data-end=\"1866\"><strong data-start=\"1809\" data-end=\"1829\">\u041f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0449\u0430 \u0434\u043e\u0437\u0430:<\/strong><br data-start=\"1829\" data-end=\"1832\" \/><strong data-start=\"1834\" data-end=\"1843\">80 mg<\/strong> \u043d\u0430 <strong data-start=\"1847\" data-end=\"1866\">\u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong><\/p>\n<\/li>\n<li data-start=\"1868\" data-end=\"1979\">\n<p data-start=\"1870\" data-end=\"1979\"><strong data-start=\"1870\" data-end=\"1915\">\u041f\u0440\u0438 \u0441\u044a\u043f\u044a\u0442\u0441\u0442\u0432\u0430\u0449 \u0443\u043c\u0435\u0440\u0435\u043d \u0434\u043e \u0442\u0435\u0436\u044a\u043a \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441:<\/strong><br data-start=\"1915\" data-end=\"1918\" \/>\u041c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 \u043a\u043e\u0436\u043d\u0430\u0442\u0430 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u043d\u0430 \u0441\u0445\u0435\u043c\u0430 (\u0432\u0436. \u043f\u043e-\u0434\u043e\u043b\u0443)<\/p>\n<\/li>\n<\/ul>\n<h4 data-start=\"1981\" data-end=\"2024\">\u2705 <strong data-start=\"1988\" data-end=\"2024\">\u0410\u043d\u043a\u0438\u043b\u043e\u0437\u0438\u0440\u0430\u0449 \u0441\u043f\u043e\u043d\u0434\u0438\u043b\u0438\u0442 \/ nr-axSpA<\/strong><\/h4>\n<ul data-start=\"2026\" data-end=\"2177\">\n<li data-start=\"2026\" data-end=\"2116\">\n<p data-start=\"2028\" data-end=\"2116\"><strong data-start=\"2028\" data-end=\"2045\">\u041d\u0430\u0447\u0430\u043b\u043d\u0430 \u0444\u0430\u0437\u0430:<\/strong><br data-start=\"2045\" data-end=\"2048\" \/><strong data-start=\"2050\" data-end=\"2059\">80 mg<\/strong> \u043d\u0430 <strong data-start=\"2063\" data-end=\"2082\">\u0432\u0441\u0435\u043a\u0438 2 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong> \u0437\u0430 <strong data-start=\"2086\" data-end=\"2099\">6 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong> (\u0441\u0435\u0434\u043c\u0438\u0446\u0430 0 \u0434\u043e 6)<\/p>\n<\/li>\n<li data-start=\"2118\" data-end=\"2177\">\n<p data-start=\"2120\" data-end=\"2177\"><strong data-start=\"2120\" data-end=\"2140\">\u041f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0449\u0430 \u0434\u043e\u0437\u0430:<\/strong><br data-start=\"2140\" data-end=\"2143\" \/><strong data-start=\"2145\" data-end=\"2154\">80 mg<\/strong> \u043d\u0430 <strong data-start=\"2158\" data-end=\"2177\">\u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong><\/p>\n<\/li>\n<\/ul>\n<h4 data-start=\"2179\" data-end=\"2227\">\u2705 <strong data-start=\"2186\" data-end=\"2227\">\u041f\u043b\u0430\u043a\u0430\u0442\u0435\u043d \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441 (\u0441 \u0438\u043b\u0438 \u0431\u0435\u0437 \u0430\u0440\u0442\u0440\u0438\u0442)<\/strong><\/h4>\n<ul data-start=\"2229\" data-end=\"2407\">\n<li data-start=\"2229\" data-end=\"2330\">\n<p data-start=\"2231\" data-end=\"2330\"><strong data-start=\"2231\" data-end=\"2244\">\u0418\u043d\u0434\u0443\u043a\u0446\u0438\u044f:<\/strong><br data-start=\"2244\" data-end=\"2247\" \/><strong data-start=\"2249\" data-end=\"2259\">160 mg<\/strong> \u043f\u044a\u0440\u0432\u043e\u043d\u0430\u0447\u0430\u043b\u043d\u043e \u2192 \u0441\u043b\u0435\u0434 \u0442\u043e\u0432\u0430 <strong data-start=\"2285\" data-end=\"2303\">80 mg \u0441\u0435\u0434\u043c\u0438\u0447\u043d\u043e<\/strong> \u043e\u0442 \u0441\u0435\u0434\u043c\u0438\u0446\u0430 2 \u0434\u043e \u0441\u0435\u0434\u043c\u0438\u0446\u0430 12<\/p>\n<\/li>\n<li data-start=\"2332\" data-end=\"2407\">\n<p data-start=\"2334\" data-end=\"2407\"><strong data-start=\"2334\" data-end=\"2348\">\u041f\u043e\u0434\u0434\u0440\u044a\u0436\u043a\u0430:<\/strong><br data-start=\"2348\" data-end=\"2351\" \/><strong data-start=\"2353\" data-end=\"2381\">80 mg \u043d\u0430 \u0432\u0441\u0435\u043a\u0438 4 \u0441\u0435\u0434\u043c\u0438\u0446\u0438<\/strong>, \u0437\u0430\u043f\u043e\u0447\u0432\u0430\u0439\u043a\u0438 \u043e\u0442 \u0441\u0435\u0434\u043c\u0438\u0446\u0430 16<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"2414\" data-end=\"2432\"><strong data-start=\"2418\" data-end=\"2432\">\u0415\u0444\u0438\u043a\u0430\u0441\u043d\u043e\u0441\u0442<\/strong><\/h3>\n<ul data-start=\"2434\" data-end=\"2661\">\n<li data-start=\"2434\" data-end=\"2528\">\n<p data-start=\"2436\" data-end=\"2528\">\u0411\u044a\u0440\u0437\u043e \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u043d\u0430 \u043a\u043e\u0436\u043d\u0438\u0442\u0435 \u043b\u0435\u0437\u0438\u0438 \u2013 \u043d\u0430\u0434 <strong data-start=\"2476\" data-end=\"2528\">80% \u043e\u0442 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438\u0442\u0435 \u043f\u043e\u0441\u0442\u0438\u0433\u0430\u0442 PASI 75 \u0434\u043e \u0441\u0435\u0434\u043c\u0438\u0446\u0430 12<\/strong><\/p>\n<\/li>\n<li data-start=\"2529\" data-end=\"2601\">\n<p data-start=\"2531\" data-end=\"2548\">\u0414\u043e\u0431\u044a\u0440 \u043a\u043e\u043d\u0442\u0440\u043e\u043b \u043d\u0430:<\/p>\n<ul data-start=\"2551\" data-end=\"2601\">\n<li data-start=\"2551\" data-end=\"2570\">\n<p data-start=\"2553\" data-end=\"2570\">\u0410\u0440\u0442\u0440\u0438\u0442\u043d\u0438 \u043f\u0440\u043e\u044f\u0432\u0438<\/p>\n<\/li>\n<li data-start=\"2573\" data-end=\"2585\">\n<p data-start=\"2575\" data-end=\"2585\">\u0415\u043d\u0442\u0435\u0437\u0438\u0442\u0438<\/p>\n<\/li>\n<li data-start=\"2588\" data-end=\"2601\">\n<p data-start=\"2590\" data-end=\"2601\">\u0414\u0430\u043a\u0442\u0438\u043b\u0438\u0442\u0438<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"2602\" data-end=\"2661\">\n<p data-start=\"2604\" data-end=\"2661\">\u0415\u0444\u0435\u043a\u0442\u0438\u0432\u0435\u043d \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 <strong data-start=\"2627\" data-end=\"2661\">\u043d\u0435\u043e\u0442\u0433\u043e\u0432\u043e\u0440\u0438\u043b\u0438 \u043d\u0430 TNF-\u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"2668\" data-end=\"2702\"><strong data-start=\"2672\" data-end=\"2702\">\u0421\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u0438 \u0440\u0438\u0441\u043a\u043e\u0432\u0435<\/strong><\/h3>\n<p data-start=\"2704\" data-end=\"2731\"><strong data-start=\"2704\" data-end=\"2731\">\u0427\u0435\u0441\u0442\u0438 \u043d\u0435\u0436\u0435\u043b\u0430\u043d\u0438 \u0440\u0435\u0430\u043a\u0446\u0438\u0438:<\/strong><\/p>\n<ul data-start=\"2732\" data-end=\"2840\">\n<li data-start=\"2732\" data-end=\"2772\">\n<p data-start=\"2734\" data-end=\"2772\">\u0418\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u043d\u0430 \u0433\u043e\u0440\u043d\u0438\u0442\u0435 \u0434\u0438\u0445\u0430\u0442\u0435\u043b\u043d\u0438 \u043f\u044a\u0442\u0438\u0449\u0430<\/p>\n<\/li>\n<li data-start=\"2773\" data-end=\"2817\">\n<p data-start=\"2775\" data-end=\"2817\">\u0418\u043d\u0436\u0435\u043a\u0446\u0438\u043e\u043d\u043d\u0438 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 (\u0431\u043e\u043b\u043a\u0430, \u0437\u0430\u0447\u0435\u0440\u0432\u044f\u0432\u0430\u043d\u0435)<\/p>\n<\/li>\n<li data-start=\"2818\" data-end=\"2840\">\n<p data-start=\"2820\" data-end=\"2840\">\u0413\u0430\u0434\u0435\u043d\u0435, \u0433\u043b\u0430\u0432\u043e\u0431\u043e\u043b\u0438\u0435<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2842\" data-end=\"2884\"><strong data-start=\"2842\" data-end=\"2884\">\u0421\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u0438 \u0438 \u043f\u043e-\u0440\u0435\u0434\u043a\u0438 \u043d\u0435\u0436\u0435\u043b\u0430\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438:<\/strong><\/p>\n<ul data-start=\"2885\" data-end=\"3127\">\n<li data-start=\"2885\" data-end=\"2949\">\n<p data-start=\"2887\" data-end=\"2949\"><strong data-start=\"2887\" data-end=\"2900\">\u041a\u0430\u043d\u0434\u0438\u0434\u043e\u0437\u0430<\/strong> \u2013 \u043f\u043e-\u0447\u0435\u0441\u0442\u043e \u0432 \u0443\u0441\u0442\u043d\u0430\u0442\u0430 \u043a\u0443\u0445\u0438\u043d\u0430 \u0438 \u0433\u0435\u043d\u0438\u0442\u0430\u043b\u043d\u0430\u0442\u0430 \u0437\u043e\u043d\u0430<\/p>\n<\/li>\n<li data-start=\"2950\" data-end=\"3063\">\n<p data-start=\"2952\" data-end=\"3063\"><strong data-start=\"2952\" data-end=\"2994\">IBD (\u0431\u043e\u043b\u0435\u0441\u0442 \u043d\u0430 \u041a\u0440\u043e\u043d, \u0443\u043b\u0446\u0435\u0440\u043e\u0437\u0435\u043d \u043a\u043e\u043b\u0438\u0442):<\/strong><br data-start=\"2994\" data-end=\"2997\" \/><strong data-start=\"3013\" data-end=\"3030\">Talz \u043c\u043e\u0436\u0435 \u0434\u0430 \u0432\u043b\u043e\u0448\u0438<\/strong> \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u043e \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435<\/p>\n<\/li>\n<li data-start=\"3064\" data-end=\"3127\">\n<p data-start=\"3066\" data-end=\"3127\"><strong data-start=\"3066\" data-end=\"3087\">\u0425\u0438\u043f\u0435\u0440\u0441\u0435\u043d\u0437\u0438\u0442\u0438\u0432\u043d\u043e\u0441\u0442<\/strong> \u2013 \u0443\u0440\u0442\u0438\u043a\u0430\u0440\u0438\u044f, \u0430\u043d\u0430\u0444\u0438\u043b\u0430\u043a\u0441\u0438\u044f (\u0440\u0435\u0434\u043a\u0438 \u0441\u043b\u0443\u0447\u0430\u0438)<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"3134\" data-end=\"3161\"><strong data-start=\"3138\" data-end=\"3161\">\u041f\u0440\u0435\u0434\u0438\u043c\u0441\u0442\u0432\u0430 \u043d\u0430 Taltz<\/strong><\/h3>\n<ul data-start=\"3163\" data-end=\"3402\">\n<li data-start=\"3163\" data-end=\"3222\">\n<p data-start=\"3165\" data-end=\"3222\"><strong data-start=\"3165\" data-end=\"3196\">\u0411\u044a\u0440\u0437 \u0435\u0444\u0435\u043a\u0442 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0436\u0430\u0442\u0430<\/strong><\/p>\n<\/li>\n<li data-start=\"3223\" data-end=\"3275\">\n<p data-start=\"3225\" data-end=\"3275\">\u0423\u0434\u043e\u0431\u0435\u043d <strong data-start=\"3232\" data-end=\"3252\">\u0435\u0436\u0435\u043c\u0435\u0441\u0435\u0447\u0435\u043d \u0440\u0435\u0436\u0438\u043c<\/strong> \u0441\u043b\u0435\u0434 \u043a\u0440\u0430\u0442\u043a\u0430 \u0438\u043d\u0434\u0443\u043a\u0446\u0438\u044f<\/p>\n<\/li>\n<li data-start=\"3276\" data-end=\"3352\">\n<p data-start=\"3278\" data-end=\"3352\"><strong data-start=\"3278\" data-end=\"3350\">\u0410\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0430 \u043f\u0440\u0438 \u043d\u0435\u0443\u0441\u043f\u0435\u0445 \u043d\u0430 TNFi \u0438\u043b\u0438 \u043f\u0440\u0438 \u0432\u043e\u0434\u0435\u0449\u043e \u043a\u043e\u0436\u043d\u043e \u0430\u043d\u0433\u0430\u0436\u0438\u0440\u0430\u043d\u0435<\/strong><\/p>\n<\/li>\n<li data-start=\"3353\" data-end=\"3402\">\n<p data-start=\"3355\" data-end=\"3402\"><strong data-start=\"3355\" data-end=\"3377\">\u041d\u0438\u0441\u043a\u0430 \u0438\u043c\u0443\u043d\u043e\u0433\u0435\u043d\u043d\u043e\u0441\u0442<\/strong> \u0438 \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u0438 \u043f\u043b\u0430\u0437\u043c\u0435\u043d\u0438 \u043d\u0438\u0432\u0430<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"3409\" data-end=\"3447\"><strong data-start=\"3413\" data-end=\"3447\">\u041e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0438\u044f \u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f<\/strong><\/h3>\n<ul data-start=\"3449\" data-end=\"3598\">\n<li data-start=\"3449\" data-end=\"3490\">\n<p data-start=\"3451\" data-end=\"3490\"><strong data-start=\"3451\" data-end=\"3488\">\u0410\u043a\u0442\u0438\u0432\u043d\u0430 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f \u0438\u043b\u0438 \u0438\u043c\u0443\u043d\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442<\/strong><\/p>\n<\/li>\n<li data-start=\"3491\" data-end=\"3538\">\n<p data-start=\"3493\" data-end=\"3538\"><strong data-start=\"3493\" data-end=\"3511\">\u0418\u0441\u0442\u043e\u0440\u0438\u044f \u043d\u0430 IBD<\/strong> \u2013 \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u0431\u043e\u043b\u0435\u0441\u0442 \u043d\u0430 \u041a\u0440\u043e\u043d<\/p>\n<\/li>\n<li data-start=\"3539\" data-end=\"3598\">\n<p data-start=\"3541\" data-end=\"3598\"><strong data-start=\"3541\" data-end=\"3576\">\u0416\u0438\u0432\u0438 \u0432\u0430\u043a\u0441\u0438\u043d\u0438 \u0441\u0430 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438<\/strong> \u043f\u043e \u0432\u0440\u0435\u043c\u0435 \u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f\u0442\u0430<\/p>\n<\/li>\n<\/ul>\n<p>Taltz (\u0438\u043a\u0441\u0435\u043a\u0438\u0437\u0443\u043c\u0430\u0431) \u0435 \u043c\u043e\u0434\u0435\u0440\u0435\u043d \u0438 \u0432\u0438\u0441\u043e\u043a\u043e \u0435\u0444\u0435\u043a\u0442\u0438\u0432\u0435\u043d <strong data-start=\"4500\" data-end=\"4520\">IL-17A \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440<\/strong>, \u043a\u043e\u0439\u0442\u043e \u043f\u0440\u0435\u0434\u043b\u0430\u0433\u0430 <strong data-start=\"4537\" data-end=\"4566\">\u0431\u044a\u0440\u0437 \u0438 \u0434\u044a\u043b\u0433\u043e\u0442\u0440\u0430\u0435\u043d \u043a\u043e\u043d\u0442\u0440\u043e\u043b<\/strong> \u0432\u044a\u0440\u0445\u0443 \u0441\u0442\u0430\u0432\u043d\u0438 \u0438 \u043a\u043e\u0436\u043d\u0438 \u043f\u0440\u043e\u044f\u0432\u0438 \u043f\u0440\u0438 <strong data-start=\"4599\" data-end=\"4621\">\u043f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u043d \u0430\u0440\u0442\u0440\u0438\u0442<\/strong> \u0438 <strong data-start=\"4624\" data-end=\"4642\">\u0441\u043f\u043e\u043d\u0434\u0438\u043b\u0430\u0440\u0442\u0440\u0438\u0442\u0438<\/strong>. \u0411\u043b\u0430\u0433\u043e\u0434\u0430\u0440\u0435\u043d\u0438\u0435 \u043d\u0430 \u0443\u0434\u043e\u0431\u043d\u0430\u0442\u0430 \u0435\u0436\u0435\u043c\u0435\u0441\u0435\u0447\u043d\u0430 \u0441\u0445\u0435\u043c\u0430 \u0438 \u0441\u0438\u043b\u043d\u043e \u043a\u043e\u0436\u043d\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435, \u0442\u043e\u0439 \u0435 \u043f\u0440\u0435\u0434\u043f\u043e\u0447\u0438\u0442\u0430\u043d \u0438\u0437\u0431\u043e\u0440 \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441 \u0434\u043e\u043c\u0438\u043d\u0438\u0440\u0430\u0449 \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0438\u0441, \u0435\u043d\u0442\u0435\u0437\u0438\u0442\u0438 \u0438 \u043d\u0435\u043f\u043e\u043d\u043e\u0441\u0438\u043c\u043e\u0441\u0442 \u0438\u043b\u0438 \u043d\u0435\u0443\u0441\u043f\u0435\u0445 \u043d\u0430 TNF-\u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438.<\/p>\n<p>[vc_row][vc_column][vc_cta h2=&#8220;&#8220; h4=&#8220;\u0422\u044a\u0440\u0441\u0438\u0442\u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433, \u043a\u043e\u0439\u0442\u043e \u0438\u043c\u0430 \u043e\u043f\u0438\u0442 \u0441 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f?&#8220; style=&#8220;custom&#8220; add_button=&#8220;bottom&#8220; btn_title=&#8220;\u0417\u0430\u043f\u0430\u0437\u0438 \u0447\u0430\u0441 \u0437\u0430 \u043f\u0440\u0435\u0433\u043b\u0435\u0434&#8220; btn_style=&#8220;custom&#8220; btn_custom_background=&#8220;#E64946&#8243; btn_custom_text=&#8220;#FFFFFF&#8220; btn_align=&#8220;center&#8220; btn_i_icon_fontawesome=&#8220;fa fa-solid fa-calendar&#8220; css=&#8220;&#8220; btn_add_icon=&#8220;true&#8220; custom_background=&#8220;#FFDED6&#8243; btn_link=&#8220;url:https%3A%2F%2Fwww.rheumatology.bg%2F%3Fpage_id%3D5548|title:%D0%97%D0%B0%D0%BF%D0%B0%D0%B7%D0%B8%20%D1%87%D0%B0%D1%81%20%D0%B7%D0%B0%20%D0%BF%D1%80%D0%B5%D0%B3%D0%BB%D0%B5%D0%B4%20%D1%81%D0%B5%D0%B3%D0%B0&#8243;]\u0414-\u0440 \u041a\u043e\u043f\u0447\u0435\u0432 \u0435 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433 \u0432 \u0421\u043e\u0444\u0438\u044f, \u043a\u043e\u0439\u0442\u043e \u043f\u0440\u043e\u0441\u043b\u0435\u0434\u044f\u0432\u0430 \u0433\u043e\u043b\u044f\u043c \u0431\u0440\u043e\u0439 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438, \u043f\u0440\u043e\u0432\u0435\u0436\u0434\u0430\u0449\u0438 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0417\u0430\u043f\u0430\u0437\u0435\u0442\u0435 \u0447\u0430\u0441 \u0437\u0430 \u043f\u0440\u0435\u0433\u043b\u0435\u0434 \u0441\u0435\u0433\u0430.[\/vc_cta][vc_cta h2=&#8220;&#8220; h4=&#8220;\u0412\u044a\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442 \u0437\u0430 \u043e\u043d\u043b\u0430\u0439\u043d \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f&#8220; style=&#8220;custom&#8220; add_button=&#8220;bottom&#8220; btn_title=&#8220;\u041e\u043d\u043b\u0430\u0439\u043d \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f&#8220; btn_style=&#8220;custom&#8220; btn_custom_background=&#8220;#7360F2&#8243; btn_custom_text=&#8220;#FFFFFF&#8220; btn_align=&#8220;center&#8220; btn_i_icon_fontawesome=&#8220;fa fa-brands fa-viber&#8220; css=&#8220;&#8220; btn_add_icon=&#8220;true&#8220; custom_background=&#8220;#D8D4F2&#8243; btn_link=&#8220;url:https%3A%2F%2Fwww.rheumatology.bg%2F%3Fpage_id%3D171|title:%D0%9E%D1%82%D0%B4%D0%B0%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B0%20%D0%BA%D0%BE%D0%BD%D1%81%D1%83%D0%BB%D1%82%D0%B0%D1%86%D0%B8%D1%8F&#8220;]\u0410\u043a\u043e \u0436\u0435\u043b\u0430\u0435\u0442\u0435 \u0431\u044a\u0440\u0437 \u043e\u0442\u0433\u043e\u0432\u043e\u0440 \u043d\u0430 \u0432\u0430\u0448\u0438\u0442\u0435 \u0432\u044a\u043f\u0440\u043e\u0441\u0438, \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u0442\u0435 \u043e\u043d\u043b\u0430\u0439\u043d \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f \u043f\u043e Viber, WhatsApp \u0438\u043b\u0438 \u0438\u043c\u0435\u0439\u043b. \u0417\u0430 \u043f\u043e\u0432\u0435\u0447\u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f \u043e\u0442\u043d\u043e\u0441\u043d\u043e \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438\u0442\u0435 \u0441\u0442\u044a\u043f\u043a\u0438 \u0438 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